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Diet for ibs11/13/2023 ![]() IBS has a substantial impact on the quality of life and social functioning ( Buono et al., 2017 Frändemark et al., 2018), and affects 5–10% of the general population ( Sperber et al., 2021). IBS is characterized by recurrent abdominal pain that is correlated with changes in stool consistency or frequency ( Lacy et al., 2016 Ford et al., 2020). Irritable bowel syndrome (IBS) is a chronic, often debilitating bowel disease because of the disorder of the brain–gut axis ( Drossman and Hasler, 2016 Ford et al., 2017). Systematic Review Registration: website, identifier registration number. The results of standard NMA and CNMA analysis of the improvement of overall IBS symptom scores or abdominal pain scores were consistent with this finding.Ĭonclusion: Lactobacillus was the most effective component for the relief of IBS symptoms Bifidobacterium and Bacillus were possibly effective and need further verification. Standard network meta-analysis (NMA) showed that Lactobacillus (RR 1.74, 95% CI 1.22–2.48) and Bifidobacterium (RR 1.76, 95% CI 1.01–3.07) were the most effective for the primary efficacy outcome (high certainty evidence) component NMA showed that Bacillus (RR 5.67, 95% CI 1.88 to 17.08, p = 0.002) and Lactobacillus (RR 1.42, 95% CI 1.07 to 1.91, p = 0.017) were among the most effective components. ![]() Eight RCTs were classified as low risk of bias. Key Results: We included 76 RCTs (n = 8058) after screening 1940 articles. ![]() The primary efficacy outcome was the relief of global IBS symptoms, and the secondary efficacy outcome was the reduction in IBS symptom scores or abdominal pain scores. A minimally contextualized framework recommended by the GRADE group was used to evaluate the certainty of evidence. Binary outcomes were compared among treatments using the relative ratio (RR). Randomized controlled trials (RCTs) examining the efficacy of probiotics and low FODMAP diet for IBS were included, with placebo, sham diet, or conventional treatments as controls. Methods: We searched Embase, Ovid Medline, and Web of Science from inception to 21 January 2021. We aimed to evaluate the most effective combinations and components among different probiotics or low FODMAP diet through component network meta-analysis (NMA). 3Department of Colorectal Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Chinaīackground: Probiotic and low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet are two commonly used management approaches for patients with irritable bowel syndrome (IBS).2Digestive Department, People’s Hospital of Zhongjiang County, Zhongjiang, China.1The Third Hospital/Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China. ![]() Chao-Rong Xie 1 † Bin Tang 2 † Yun-Zhou Shi 1 Wen-Yan Peng 1 Kun Ye 1 Qing-Feng Tao 1 Shu-Guang Yu 1 Hui Zheng 1* Min Chen 3* ![]()
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